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Acute kidney injury (AKI) refers to the abnormality of kidney structure and function (including abnormal blood, urine, histology and imaging examination) within 3 months of disease course. resulting in clinical syndromes with different clinical manifestations.

In recent years, some new and more sensitive biomarkers of AKI have been discovered in clinical and laboratory studies, which can not only diagnose AKI before serum creatinine rises, but also provide help for the etiological diagnosis of AKI.

NGAL        The best index for early diagnosis of acute kidney injury

CYS-C     The best endogenous index of glomerular filtration rate

β2-MG      Monitoring indicators of proximal tubule function

MAU         Sensitive indicator of early or mild kidney injury

Neutrophil Gelatinase-Associated  Lipocalin (NGAL)

NGAL is a member of the lipocalin family and normally maintains low levels in urine and blood. In the early stage (2h) of acute kidney injury (AKI), the level of NGAL in urine and blood increased significantly, and NGAL appeared before other indicators. Therefore, NGAL is one of the most effective biomarkers for the diagnosis of AKI, and its changes are earlier and more significant than traditional AKI diagnostic indicators.

Clinical significance: 

- The best index for early diagnosis of AKI

- Chronic kidney disease, early detection of diabetic nephropathy

- Early detection and prognostic evaluation of AKI complicated by various operations

- Prognostic evaluation of kidney injury complicated by renal transplantation

- Early diagnosis of cardiovascular disease patients and ICU patients complicated with renal disease

Applicable departments: 

Nephrology, emergency, interventional, ICU, cardiology, surgery